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The concentration of bicarbonate varies little from tissue to tissue with one notable exception.
碳酸氢盐的浓度在差别构造中变革不大，但有一个分明的破例。
In the epididymis, the tube in which mature sperm are stored, it is a fifth of the usual level.
在贮存成熟精子的附睾管中，碳酸氢盐的浓度是通常程度的五分之一。
The significance of this is that, at ejaculation, a tiny pellet of sperm is pushed forward and mixed with seminal fluid, suddenly quintupling the bicarbonate concentration.
这种状况是由于，射精时一小团精子与精液混淆，碳酸氢盐浓度霎时进步五倍。
That causes sAC to produce a bunch of cAMP.
这招致sAC发生少量的cAMP。
This increase in cAMP then activates the sperm, and lets them start swimming and searching for an egg to fertilise.
cAMP的添加会激活精子生机，让它们开端挪动并寻觅卵子受精。
TDI-11861 blocks the places on sAC where bicarbonate would normally bind, rendering it unresponsive to this rapid change in concentration.
TDI-11861阻断了sAC上碳酸氢盐正常联合的点位，不让其对浓度的疾速变革发生反响。
That stops them swimming.
这会制止精子挪动。
Although TDI-11861 inhibits sAC everywhere in the body, Dr. Buck and Dr. Levin say this is not a cause for concern.
虽然TDI-11861会克制体内到处的sAC，但巴克博士和莱文博士表现，这没什么好担忧的。
Some men lack functioning sAC because of a mutation.
一些男性由于基因渐变而缺乏正常的sAC。
That results in infertility and a slightly raised incidence of kidney stones, but otherwise they are completely normal.
这会招致不孕不育和肾结石发病率略有上升，但除此之外是完全正常的。
So, while sAC appears to be a unique link in the chain of sperm mobilisation, the body has built plenty of redundancy into its means of generating cAMP.
因而，虽然sAC好像是精子挪动链中的一个共同关键，但人体在其天生cAMP的进程中制造了少量的冗余。
Whether Dr. Buck's and Dr. Levin's discovery will actually prove to be the long-sought breakthrough in the search for a Pill for men remains to be seen.
巴克博士和莱文博士的发明能否真的会成为迷信家临时以来不时寻觅的，在男性避孕药方面的打破，另有待察看。
More animal tests will be needed before trials on people can go ahead.
在停止人体实验之前，还需求停止更多的植物实验。
The two researchers are, however, already looking at other sAC-inhibiting compounds, to determine which performs best.
但是，这两位研讨职员曾经在寻觅别的可以克制sAC的化合物，以确定哪种化合物体现最好。
One approach they use is x-ray crystallography, which shows how molecules fit together at an atomic level.
他们运用的办法之一是x射线晶体学，它可以在原子程度上展现分子的陈列方法。
With it, they have improved how well their compound binds to the right spot on sAC, and stays there - and they hope to do better still.
有了这项技能，巴克博士和莱文博士对化合物在sAC上的准确地位联合，并停顿在那边的才能停止了改进——而且，他们盼望做得更好。
Right now, men have less control over family planning than women do, and sometimes feel little responsibility for it.
现在，从方案生养的角度来说，男性支付的比女性少，而且时常以为他们不需求为此担任。
That is surely not unconnected with the fact that, according to the United Nations Population Fund, nearly half of pregnancies - 121m each year - are unplanned.
这也就形成了如许一个现实：依据结合国生齿基金的数据，每年1.21亿次有身中，近一半是不测有身。
"This", Dr. Levin says, referring to sAC inhibition, "gives men the ability to be a partner."
“sAC克制剂这一发明，”莱文博士说，“付与了男性成为朋友的才能。”
Who knows?
谁晓得呢？
Some of them might even give it a try.
有些人乃至能够会试一试。
